MRes projects – 2022 entry

The research priorities in Biological Sciences at Edge Hill University span three interlinked strands: Biomedical Science, Ecology and Genetics.

  • Biomedical Science research priorities often take a genetics-based approach and include research into regulation of endocrine hormone expression, rare skin diseases, pregnancy complications, wound healing, neuroscience, gene therapies and nanotherapeutics.
  • Ecology priorities include research into forest adaptations to climate change, mitigating impacts of habitat change on biodiversity, conservation of species in rare habitats and sustainable management of ecosystems.
  • Genetics research priorities include insect vectors of disease, plant evolution, divergent eukaryotic stress response mechanisms, soil microbiology and antibacterial discovery.

Across these biological sub-disciplines, we collaborate with researchers from around the Globe as well within Edge Hill University, utilising cutting-edge technologies.

The University in this recruitment round welcomes applications for MRes candidates in the projects shown below.

For an initial discussion about these projects please contact Dr Aristides Tagalakis, the Biology Department Research and Postgraduate coordinator, by emailing [email protected]

MRes projects

MRes projects are available in our three interlinked research themes:

Biomedical Science (basic investigations and new therapies for diseases)

  • Novel therapeutics to target Ocular Fibrosis.
  • Extracellular vesicles as Cancer Biomarkers.
  • Development of mucus-penetrating nanocarriers for Cystic Fibrosis.
  • Cystic Fibrosis: can we make more CFTR protein using novel gene therapy vectors for the most severe cases?
  • Investigating strategies to stimulate inflammatory cell clearance of bacteria during hormone-driven ageing.
  • Blood-brain barrier disruption in cardiovascular disease.
  • The role of HOXA10 in embryo-endometrial attachment in the context of the endocrine disorder polycystic ovary syndrome.
  • Analysis of heterogeneity in hormone gene expression in pituitary cells.

Ecology and Evolution

  • Urban biodiversity – the value of green spaces for invertebrates.
  • Plantations and woodland biodiversity, including those associated with dead wood and/or the canopy – species, traits and ecosystem function. A collaboration with forest research.
  • The impact of grazing approaches on biodiversity in upland habitats. A collaboration with the RSPB.

Genetics and Vector Biology

  • Pulling the emergency brake: is TbEro1 the trigger for the cell cycle arrest in Trypanosoma brucei during VSG stress?
  • A lethal makeover: can Trypanosoma bruceisurvive on an atypical surface coat?
  • Characterising the role of macrophage infectivity potentiators (MIPs) in the non-pathogenic organism Streptomyces coelicolor.
  • Characterization of antibiotic production potential of newly isolated Streptomycesstrains.
  • Genetic manipulation of biosynthetic gene clusters form Streptomycesspecies to increase antibiotic production.
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