Dr Dorothy Tse

Profile

Biography

My lab specialises in investigating the neurobiology of memory, with a particular focus on understanding how the brain processes and retains new information. My research explores the impact of various factors on different types of memory, including episodic (events), semantic (facts and knowledge), and spatial memories.

My lab has three main research themes:

1. Investigating the influence of prior knowledge, novelty, and curiosity on the processes underlying learning and memory formation.
2. Examining the effects of aging and dementia on memory and the brain.
3. Developing behavioural paradigms that bridge the gap between animal models and human memory research, enabling translational studies.

To gain insights into the mechanisms underlying memory and learning, I employ a diverse array of experimental techniques, including behavioural analysis, virtual reality, electroencephalography (EEG), and transcranial magnetic stimulation (TMS). These methods are used to gain insights into the underlying mechanisms of memory and learning.

The Tse lab collaborates with a variety of patient and public involvement groups and charities to promote healthy aging and brain health. The lab has worked with the University of the Third Age (u3a) Ormskirk and Aughton to promote active ageing and behavioural change in Northwest UK communities. I have also collaborated with the University of Bournemouth and Healthwatch Dorset on a project funded by Alzheimer’s Research UK to promote healthy brain health in ethnic minority communities. Additionally, the Tse lab works with the Early Onset Dementia Group at Walton Centre, UK, to improve knowledge of health and wellbeing.

• Anterior cingulate cortex in schema assimilation and expression
• Schema-dependent gene activation and memory encoding in neocortex