Dr Dorothy Tse

Dr Dorothy Tse

Information

Research Qualifications
I am interested in understanding the neurobiology of learning and memory, in particular, how different factors affect episodic, semantic and spatial memory. These different factors include emotion, novelty, prior knowledge, etc. I am also investigating different strategies to alleviate mild cognitive impairment and dementia symptoms. Although our understanding has greatly improved in recent years, there are still many important things that we do not know, such as why we remember some events yet forget others, and how the brain encodes memories and subsequently transfers them to long term memories.

My current lines of research are:
We learn new things better when we can relate them to prior knowledge (a schema). The concept of schemas was introduced in human psychology around 100 years ago. However, the neurobiology of schema is not well known. Previously, my colleagues and I found that new information can be assimilated into neocortical schemas very rapidly via systems consolidation. I am now investigating possible mechanisms underlying schema formation and how information is assimilated into a schema. This may also have implications for educational aspects of learning and memory.

Are there any effective behavioural methods to delay memory decline, especially in early stages of dementia? Recent research using animal models has indicated possible ways to improve memory. However, translational studies with humans and animals remain challenging. I am interested in looking into different therapeutic strategies to alleviate cognitive impairment and delay memory decline in dementia.

BSc in Biotechnology– Hong Kong Baptist University
MSc in Neuroscience (Dist)- University of Edinburgh
PhD in Neuroscience – University of Edinburgh
Fellow of Higher Education Academy
Teaching Contact
To be confirmed Dr Dorothy Tse
Department of Psychology
Edge Hill University
St Helen’s Road
Ormskirk
L39 4QP
Phone:
Email: Dorothy Tse
Office: LP 2.16
Web: https://dorothytse.com/

Publications

Full-text links of these publications are available on the Edge Hill University Research Information Repository.

Alonso A, van der Meij J., Tse D, Genzel L. (2020) Naïve to expert: Considering the role of previous knowledge in memory. British Neuroscience Advances.

Broadbent N, Lumeij L, Corcoles M, Ayres AI, Ibrahim Z, Masatsugu B, Moreno A, Carames JM, Begg E, Strickland L, Mazidzoglou T, Padanyi A, Munoz M, Takeuchi T, Peter M, Morris RGM and Tse D (2020). A stable home-base promotes allocentric memory representations of episodic-like everyday spatial memory. EJN. ejn.14681

Wang SH, Tse D and Morris RGM (2012) Anterior cingulate cortex in schema assimilation and expression. Learn Mem. 19: 9315-318

Tse D, Takeuchi T, Kakeyma M, Kajii Y, Okuno H, Tohyama C, Bito H and Morris RGM (2011) Schema-Dependent gene activation and Memory Encoding in Neocortex. Science. 333: 891-895

Bethus I, Tse D and Morris RGM (2010) Dopamine and memory: modulation of the persistence of memory for novel hippocampal NMDA receptor-dependent paired associates. J Neurosci. 30, 1610-1618

Tse D, Langston R F, Bethus I, Wood E R, Witter M P and Morris R G M (2008) Does assimilation into schemas involve systems or cellular consolidation? It’s not just time. Neurobiol Learn Mem. 89:361-365

Tse D, Langston R F, Kakeyama M, Bethus I, Spooner P A, Wood E R, Witter M P and Morris R G M (2007) Schemas and memory consolidation. Science, 316, 76-82

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